• Subcutaneous implantation

  • Orthotopic implantation

  • Drug efficacy

  • Drug toxicity

  • In vitro 2D work

  • Organoids

Repository of live tumor tissue​​​, with standard data set:

  • Whole exome sequencing and gene expression  

  • Histopathology of early passage PDX and originating patient specimens.

  • Growth curves of consecutive PDX passages

  • Bladder

  • Breast 

  • Carcinoma

  • Glioblastoma

  • Melanoma

  • Neuroblastoma

  • Pancreatic

  • Prostate

  • Drug resistant models

  • Bruker BioSpec 94/20 9.4 Tesla MRI

  • VEVO 2100 Ultrasonic Imaging System

  • VEVO 2100 Analysis Software (VevoCQ)

  • IVIS Spectrum Bioluminescence and Fluorescence Optical Imaging

  • Living Image 4.4 Optical Imaging Analysis Software

  • Perkin-Elmer Quantom FX micro-CT Imaging System

Next Generation Sequencing (NGS)

  • Patient's tumor is processed to identify cancer driver genes or networks.

  • FDA approved drugs known to target these genes are used to treat the primary tumor, in vivo, using PDX mice models to validate their efficacy.

Herbert Irving Comprehensive Cancer Center

1130 Saint Nicholas Ave. Room 216 | New York, NY 10032

O.P.T.I.C. © 2019

All images and information are the copyright of the Columbia University Medical Center Oncology Precision Therapeutics Imaging Core and specific approval must be given prior to reproduction or use.